Bitcoin-only
Simpler stack. No altcoin volatility inside the same loan book. Often clearer product focus.
Multi-asset
More flexibility in what you pledge. Infrastructure and liquidation behavior may be built for many assets, not only Bitcoin.
Resources / Risk & custody
Bitcoin-only keeps the stack simple. Multi-asset platforms add flexibility and more operational complexity.
Simpler stack. No altcoin volatility inside the same loan book. Often clearer product focus.
More flexibility in what you pledge. Infrastructure and liquidation behavior may be built for many assets, not only Bitcoin.